![]() Unfortunately, a multicenter study reported existence of significant discrepancies in the results of JAK2 V617F mutant allele burden quantitation when blinded samples were tested across some of the most specialized health institutes, which delineated the importance of using well-defined, accurate standards to refine JAK2 quantitative assays. There have been great efforts to improve the accuracy of detecting and quantifying JAK2 V617F mutation, such as allele-specific loop-mediated isothermal amplification, addition of a wild-type JAK2 blocker (any one of a non-extendible dideoxy oligonucleotide, a locked nucleic acid, and a peptide nucleic acid) to limit amplification to be mutant-specific in a quantitative PCR (q-PCR) reaction, and restriction fragment nested AS-PCR. Among these diagnostic techniques, AS-PCR seems to be the most commonly used method and allows detection of an allele burden as low as 1% however, the obtained results are usually ambiguous. These studies highlight the importance of precise determination and quantification of JAK2 V617F mutant allele burden in afflicted individuals.Ī large number of diagnostic techniques have been applied in the detection of JAK2 V617F mutation in MPNs, including direct sequencing, pyrosequencing, denaturing high performance liquid chromatography, restriction enzyme digestion, melting curve analysis, amplification-refractory mutation system, and allele-specific polymerase chain reaction (AS-PCR). For example, MPN patients with higher allele burden of JAK2 V617F are more likely to suffer from major thrombotic events. Previous studies have demonstrated that JAK2 V617F homozygosity could drive phenotypic switch from ET to PV in mice models, and the higher allele burden in PV than in ET as seen in clinical studies is associated with unique disease phenotypes even within a specific MPN subtype. In particular, allele burden of JAK2 V617F carries important pathogenetic and clinical significances in MPNs. In regard to classical MPNs, mutations in JAK2 include JAK2 V617F hotspot mutation and exon 12 mutations. ![]() Mutations in any one of the mutually exclusive driver genes result in constitutive activation of downstream signaling cascades, which in turn leads to clonal proliferation of hematopoietic precursors and excessive production of terminally differentiated, fully functional blood cells. A hallmark of the genetic background of MPNs that constitutes the diagnostic criteria of World Health Organization (WHO) classification is MPN-restricted driver mutations, including those in Janus kinase 2 (JAK2), calreticulin (CALR) and myeloproliferative leukemia virus (MPL). MPNs include three major clinical entities, i.e., polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). BACKGROUNDĬlassical myeloproliferative neoplasms (MPNs) are multipotent hematopoietic stem cell disorders characterized by excess production of various blood cells. The disclosure relates to a method of quantifying a mutant allele burden of a target gene by using a recombinant plasmid pair as a standard. The instant application contains a Sequence Listing which has been filed electronically in ASCII format.
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![]() ![]() It isn't long tho before those pesky infected folk come knocking on, or rather crashing thru, the door & Don leaves his wife to be devoured rather than run back to try to save her & face certain doom himself.Ģ8 Weeks later we find Don being reunited with his 2 kids Andy (Muggleton) & Tammy (Poots) who are returning to be re-patriated having, apparently, been living safe & sound in Spain(?). The film opens with Don (Carlyle) & his wife Alice (McCormack) holed up with a few other survivors in a country house. And it succeeds where 28 Days failed by sticking to the principles it starts with! the zombie chase scenes thru the mansion were sooooo bad they'd have been left on a 70's B movie cutting room floor & such a screeching, abrupt ending that i wondered what the cast & crew were in such a hurry to get away from? Great film ruined by a poor ending.Ģ8 Weeks isn't trying to be intelligent, subtle or understated. The sub-plot with the British soldiers really intrigued me & added a psychological factor. It was more intelligent, subtle, understated. Jon FosterĪpart from still being set in Britain, the words '28' & 'Later' in the title, the 'Rage' virus & lots of zombie-esque folk chasing the as-yet uninfected for a bite to eat (gives a new meaning to fast food!) this film really has nothing in common with it's predecessor.Ģ8 Days wasn't trying to be an action-packed, gore-fest zombie movie. But its a very good, energetic horror movie, and far, far better than you might've originally given it credit for. Whats more, it opens up the enticing possibility of a further sequel, and on the evidence of this film, thats a very welcome thought.Ģ8 Weeks Later, like its predecessor, isnt a film for the faint-hearted, and wholesome family entertainment it absolutely isnt. Grounded by Robert Carlyle as one of the survivors of the virus, replete with his kids in tow, 28 Weeks Later skilfully navigates the labyrinth of sequel hell and really, really delivers. Only things quickly go wrong, allowing Fresnadillo to mould a pacey, exciting and desperately enjoyable action carnival, thats got a little more under the surface. Primarily set over six months after the Rage virus engulfed Britain, turning many of its inhabitants into deadly zombie-esque creatures in the process, the film this time though sees the American military arrive to help sort things out. Many of the building blocks are the same. And Fresnadillo is an inspired choice, putting together a film thats not bereft of flaws of its own, but one that proves to be an ambitious and surprisingly thought-provoking follow-up. 28 Weeks Later really is a sequel that delivers, that expands on the original, and in many ways even surpasses it.įaithful in many ways to the enjoyable, if derivative, 28 Weeks Later, this sequel sees original director Danny Boyle (who went off to make Sunshine instead) replaced by Juan Carlos Fresnadillo behind the camera (director of the excellent Spanish film Intacto ). Put that cynical look away, because the critics were right. Starring Rose Byrne, Jeremy Renner, Catherine McCormack. Have a good time forwarding.Directed by Juan Carlos Fresnadillo. We try to make the process of being on the site more convenient and easy to view and download photos, pictures, wallpaper on your desktop that you liked. There are no restrictions on daily downloads.Īll photos are checked for quality, so you get only beautiful desktop wallpapers. A search system for multiple tags will give you the ability to quickly find the wallpapers or pictures you are interested in.Īfter a quick registration, you can add all the photos to your favorites, so that you can quickly find what you like.Ībility to sort by resolution or aspect ratio can help you find the largest and highest quality pictures on your desktop or for mobile phone. You can search by many different resolutions, like horizontal, so and vertical for mobile phone. We do not adhere to very strict rules for the aspect ratio of images, so you can find both familiar wallpapers and simple pictures for the desktop, without any clippings or captions on the image. Good day, on this site you can quickly and conveniently download free wallpapers for your desktop.Ĭonvenient green "Download" buttons allow you to upload images without any additional interference. ![]() Want to see more images from a folder? Now you can. ![]() Once you chose a bakground image instead of the plain color, why not give a try to the new, centered folder title? Naturally, the old – left aligned – title still exists, moreover you can align it vertically too. PRO TIP: if you want the header image only be used in the header, first drag´n´drop to the right panel´s “Theme image” area, then right-click → Exclude If your album doesn´t have an appropriate, toned-down image, you can download one from Unsplash– e.g. Instead of the plain header now you´ll be able to use a background image too. You can choose from 4 different thumbnail layouts: Fixed shape grid, Grid, Masonry (horizontal) and Cards (vertical) I hope existing users will easily accustomed to this, and Tiger or Projector users will find it already familiar. The new layout tries to sort the settings according to where they appear on the page: Header, Sections, Side bar, Footer, Lightbox. I know those who has accustomed to the old organization might feel lost finding a particular setting in the new one. The user interface has been totally redesigned. Perhaps too much tech detail here, but I wanted to bring this up because this has been the hardest part of the upgrade. And besides this, makes easy to develop and fix bugs in these skins parallel. Apart from being much easier for me to code in Javascript, it is good for the users too, as it runs much faster under jAlbum. The coding language of the skin – originally BeanShell (a Java-like language) – has changed to Javascript. ![]() Today more than 99% of users has flex-capable browsers, and although Internet Explorer 11´s implementation is buggy, MS Edge works well. Feels like we´ve skipped to the 21st century. Did you know previously there was no proper way of aligning an image vertically and horizontally centered within a box? Crazy, isn´t it? The new flex layout even makes it possible achieving the so-called “masonry layout” (horizontal tiles) without a line of code. This makes it possible to align items within a container box (and relative to each other) horizontally or vertically whatever you like. jalbum folder of the album project's root folder in order to speed up the rendering)įlex layout is what web designers were always phantasized about. (Web snapshots are being cached on disk within the. When you initially open and browse the Project Gallery it will take some time for the web snapshots to populate the view, and you might notice some flickering, but once it's done, operating the Project Gallery is fast. This may be needed if the album wasn't done rendering the initial display when the snapshot was being taken. Preview opens the project's album in jAlbum's default web browser and "Reload" forces jAlbum to recalculate a snapshot of the web preview. It currently has the options "Open", "Preview" and "Reload". If you right-click an album project it will reveal a contextual menu. To do so, simply hold down SHIFT or ALT as you open a project. Just like Windows Explorer, the Project Gallery has a quick search function whereby it alternates between all projects beginning with the letter you type.Īs you open a project, the gallery closes, but you can keep it open and move it next to the main window to quickly browse between projects. To open a project simply double click it or navigate using the cursor keys and hit Enter. The ordering can also be flipped between recent, alphabetical and reverse alphabetical. It defaults to presenting the recent projects, which may reside anywhere on your computer but you can alternatively choose to list all album projects found under the "My Albums" folder. The Project Gallery presents a grid of large thumbnail images for each album project. You can even double click the "Recent projects" label (project ordering label) to open the Project Gallery. ![]() To access the Project Gallery either press CTRL/CMD+G, select File->Project Gallery or hit the new project gallery button located just to the right of the new project button. no web files present), then the gallery resorts to displaying a large version of the representing thumbnail instead. Enter the new Project Gallery! This window presents large thumbnail images of web previews of each album project. The "Recent project" list helps, but the thumbnail images are rather small. With active regular use of jAlbum over some time you end up with a huge amount of album projects. The main improvements in this version is a faster album uploader and the new Project Gallery - the subject for this blog post. ![]() ![]() Each has features that set it apart from the rest.
Check to see if your inmate’s facilityoffers video visitation.Please note: These services can vary by facility and are not available at all locations. Then, conduct the visit in real-time over the internet. Through our easy-to-use website, you can schedule, register, and pay for (if applicable) the visit in advance. With these visits, you are still required to travel to the facility. On-site video visits are conducted at visitation stations at the facility. Save travel expenses, time, long lines and parking fees with at-home video visits.Įase stress on children who can now communicate without visiting the facility in person. These video visits can be conducted at home on your PC computer, laptop or mobile device (Android). ![]() We offer two types of Video Visitation services: At-Home Video Visits Visits can be scheduled and paid for in advance, allowing you to visit with inmates at times that are convenient for you. Video visitation is a great way to connect with your loved one over the internet, without having to worry about unpredictable crowds and overly busy visitation hours.
![]() The value assigned to IPv4 is your router's IP address. Step 4: In the pop-up box, click on “Details”.Īfter clicking on the “Details” button, another small window will pop up showing various information about your router. ![]() Click on it and a small window will pop up. Step 3: You will see your router name on the right. Step 2: Under “Network and Internet”, click on “View network status and tasks”. Step 1: Click on Start and search for “Control Panel”, then click on the first search result or hit ENTER to launch the Control Panel. How to Find your Wifi Address on a Windows Computer through the Control Panel The number assigned to “Default Gateway” is your router’s IP address. Step 3: Right inside the command prompt, type in “ipconfig” and hit Enter. Step 2: Search for “cmd” and hit ENTER to launch the command prompt. Step 1: Click on Start (Windows logo) or press the WIN on your keyboard. How to Find your Wifi Address on a Windows Computer through the Command Prompt To find out what the IP address of your router is (or of any other device on which you have access to its Wifi), you can either use the command prompt or gain access to it through the control panel. How to Find your Wifi Address on a Windows Computer The internet protocol is a set of rules governing how computers, phones, and other devices share data over the internet or local networks.Īn IP address is a special numerical identifier that allows information to be sent between various devices on a network. The abbreviation IP stands for “internet protocol”. What is an IP Address?īut before we jump in, let's clarify – what is an IP address? In this article, I will show you how to find out what your router IP address is on a Windows machine and Android smartphone. This will give you access to the setup page so you can make configuration changes like changing passwords, kicking out unwanted users, limiting users, and so on. Note: Most users have a Dynamic IP Address that keeps changing unlike a Static IP Address which remains the same and does not change.Sometimes you might need to know your router’s IP address. On the next screen, you will be able to see your Private IP Address. Go to Settings > WiFi > tap on gear shaped Settings Icon.Ģ. ![]() ![]() Similarly, it is also easy to obtain your Private IP Address on an Android Phone.ġ. On the next screen, your Private IP Address will be listed next to IP Address Entry under “IPV4 ADDRESS” section.Ĥ. Go to Settings > WiFi > tap on your WiFi Network Name.Ģ. On an iPhone, you can follow the steps below to find your Private IP Address.ġ. In the right-pane, your Private IP Address will be listed next to IPV4 Address entry. Select your Network Type ( Ethernet or WiFi) in left-pane. On System Preferences screen, click on the Network option.ģ. Click on Apple icon in top menu bar and select System Preferences in the drop-down.Ģ. If you are using a MacBook, Mac Mini or iMac, you can follow the steps below to find your Private IP Address.ġ. In Addition to the usual 4 string IPV4 address, you will also see your IPV6 IP Address, which will be in the form of a complex combination of letters and numbers. On Network Properties screen, you will see your Private IP Address listed next to iPv4 address entry. In the right-pane, click on Properties button for the active Network on your computer.ģ. On the next screen, select Status in left-pane. Open Settings > click on Network and Internet.Ģ. Find Private IP Address in Windows 10įollow the steps below to find your Public and Private IP Addresses on a Windows 10 computer.ġ. The Private IP Address can be easily viewed on PC, Mac, iPhone and Android Phones by using steps as provided below for each of these devices. Your Private IP Address is assigned by Modem/Router to devices like Computers, Phones and others and this is only visible to devices within your Home WiFi Network. To find your Public IP Address (iPv4), you can trust ip4.me or visit other websites listed in the search results. In most cases, both Chrome and Safari browsers will be listing your IPv6 address in the top search result. Your Public IP Address is assigned by the ISP (Internet Service Provider) and this can be easily viewed by typing What is my IP Address in Chrome, Safari and other web browser. In short, the External IP Address (assigned by Service Provider) can be seen by other devices on the internet, while the Internal IP Address is not visible to other devices on the internet. The Internal or Private IP Address is assigned by the Modem to your Computer, Phone and other devices and this can only be seen by other devices using the same WiFi Network. However, for permanent installations, I’d advise to either stick the camera on a metallic surface, or to use the metal plates provided.įor storage, there are a couple of options available to you. Instead, you’ll have to rely on careful placement and a 130-degree field-of-view.Įven if you place it on a non-metallic surface, the C1C is well-weighted enough to stay upright for the most part. Like other entry-level CCTV cameras, the EZVIZ C1C does not have any sort of motorised ability. Reminiscent of early generation WiFi cameras, the C1C has a hockey puck-shaped head, mounted onto a circular, magnetic base via a thin stem. ![]() If you’re looking for something that adds a special touch to your home’s interior design, this isn’t it. The simple nature of the app has also been carried over to the design of the EZVIZ C1C camera. Keep in mind that most of the C1C’s functions are controlled here instead of the Google Home app, so I certainly appreciate the simple-and functional-nature of the EZVIZ mobile app. On the homepage, you’ll see all connected cameras with quick access buttons for settings and motion alerts, while two more tabs cover notifications and advanced settings. The EZVIZ app, meanwhile, feels intuitive and simple to use. However, a delay of around 15 seconds means that you’ll only be able to use the C1C as an effective doorbell monitor via the real-time feed on your EZVIZ app-unless your guests are okay with you taking 15 seconds to open the door. These include the ability to turn motion alerts on/off with Google Assistant, integrate the camera into your Smart Home Routines, and my personal favourite: to stream the C1C’s feed on a Chromecast device in real-time (albeit with video encryption turned off via the app). If you prefer, you can still use the C1C as a standalone device without Google Home-although you’ll miss out on voice commands and other benefits. ![]() With that done, I proceeded to integrate the C1C with my existing Google Home ecosystem by adding EZVIZ as a linked partner in the Home app. Overall, the basic setup process took under five minutes to complete for me.
diseases-conditions/stroke/symptoms-causes/syc-20350113 diseases-conditions/guillain-barre-syndrome/symptoms-causes/syc-20362793 aao.org/eyenet/article/lagophthalmos-evaluation-treatment Nocturnal lagophthalmos: An overview and classification. aao.org/eyenet/article/advice-better-ptosis-surgery-from-three-experts Advice for better ptosis surgery from three experts. What is ptosis? aao.org/eye-health/diseases/what-is-ptosis You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Those with this disorder are unable to pucker their lips, smile, frown, raise their eyebrows, or close their eyelids. Moebius syndrome is a rare disorder causing weakness or paralysis of the facial nerves. When this happens, a person can lose control of the muscles on their face, including in their eyelids. Some autoimmune conditions, such as Guillain-Barré syndrome, attack the body’s own nerves. ![]() Autoimmune conditions, such as Guillain-Barré syndrome ![]() Sometimes when surgery is done to remove these tumors, parts of the nerves are damaged.īoth of these conditions can cause a loss of control over the eyelids, causing them to stay open at night. Tumor, or tumor surgery near the facial nerveĪ tumor near the nerves that control facial movements can reduce the face’s ability to move, or even paralyze the face. Seek immediate medical assistance if someone has drooping on one side of their face. Sometimes brain cells controlling nerve function and basic movements of the face are killed, causing paralysis of the face. This prevents oxygen from getting to the brain, causing brain cells to die within minutes. Strokeĭuring a stroke, the blood supply to your brain gets reduced or cut off. Injuries that result from cosmetic surgery, such as eyelifts, may also cause damage to the nerves that control movement in the eyelids. Trauma or injury to the face, eyes, or nerves that control eyelid movement could affect your ability to shut your eyes. A person with Bell’s palsy may not be able to close their eyes during sleep.Įighty percent of people with Bell’s palsy recover within six months, but without proper eye care and injury prevention, it’s possible to permanently injure your eyes. Bell’s palsyīell’s palsy is a condition that causes temporary weakness or paralysis of the nerves that control movements in the face, eyelids, forehead, and neck. This results in sleeping with eyes partially open. While surgery can help correct this condition, a common complication during surgery could keep the eyelid from shutting completely. This condition, called ptosis, is associated with the weakening or injury to the muscle that lifts the eyelid. ![]() ![]() Some people have a drooping upper eyelid. Nocturnal lagophthalmos is associated with physical abnormalities of the eyes, face, or eyelids, or eyelashes that grow into the eyes. Most with this condition have eyelids that cannot close enough to cover the eye partly or completely. Most people who cannot close their eyes while sleeping have a condition called nocturnal lagophthalmos. Here are some of the most common reasons for sleeping with your eyes open: Nocturnal lagophthalmos These might be related to neurological problems, physical abnormalities, or other medical conditions. There are several possible reasons that a person may not be able to sleep with his or her eyes open. By the CD era, the various labels that controlled the songs were no longer happy to license their material, and the album went out of print, although a CD was issued overseas in 1993. Its very success ironically doomed the availability of the Easy Rider soundtrack album, however. Just as the film transformed values in Hollywood, the soundtrack album helped give birth to a new business in which soundtrack albums became collections of various pop songs that sometimes out-grossed the films with which they were associated. The result was a commercial bonanza: The album reached the Top Ten and went gold, becoming the second most successful soundtrack LP of the year, after the Nino Rota score to Romeo and Juliet. The soundtrack album also featured some dialogue and sound effects from the film. Only Capitol Records held out, so the Band's version of "The Weight" was replaced by a near-copy recorded by Dunhill act Smith. When Easy Rider became a successful film upon release, a decision was made to release a soundtrack album, and most labels agreed to license their tracks to Dunhill/ABC. Roger McGuinn, making his solo performing debut, contributed new recordings of Bob Dylan's "It's Alright Ma (I'm Only Bleeding)" and his own specially written "Ballad of Easy Rider," actually co-written with Dylan, who was not credited. So, the film's music consisted of such 1968 rock radio favorites as Steppenwolf's "The Pusher" and "Born to Be Wild," the Band's "The Weight," the Byrds' "Wasn't Born to Follow," and the Jimi Hendrix Experience's "If Six Was Nine," with such humorous changes of pace as the Holy Modal Rounders' cosmic folk song "If You Want to Be a Bird" and Fraternity of Man's marijuana-smoking behavior guide "Don't Bogart Me." Hopper had little trouble persuading various record labels to grant the screen rights to these songs at a time when re-used rock wasn't heard much in movies. (In the liner notes to the 2000 CD reissue, Hopper claims that he canceled a proposed Crosby, Stills, Nash & Young score when he became enamored with his own selections other accounts claim the film studio insisted on the music used in the rough cut.) Even then, director Dennis Hopper didn't have much special music written, instead mostly using songs he'd heard on the radio in 1968 while he was editing the film. It turned out to be a telling portrait of America's cultural divide in the late '60s, and no small part of its impact was the soundtrack music, which eschewed a traditional score (the filmmakers couldn't have afforded that, anyway) in favor of rock music. Easy Rider was the surprise box-office hit of the summer of 1969, a low-budget film about a couple of hippies who use their profits from a drug deal to drive their motorcycles across the Southwest and attend New Orleans' Mardi Gras celebrations, encountering adventures and tragedy along the way. |
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